???????

2016071409:40  ?-?
 

2016312????????????????????????????????????֍I?????

?

??2011

?????EGFR????????NSCLC?????????????????NSCLC??????

?????????˧?????80%?75%?????5????????????????

2014???????61,160??50.08%29.78%20.15%?2014???2012~2014??-0.51%-9.35%87.78%

?2011ԧ????????????????????QALY??????????25/QALY35/QALY46/QALY

?QALY??,?????

??

??

??2008

??????????????

??????2.9???2.7???20%????????75????????????H ?????H ?????????????????????

????????ATC4 C09AA20122.24%?2015?7.03%20125.57%2015?4.05%??2012~2014???67.5%????????

??2009???2013???????????

??

?

??2014

????????AMD

?AMD?50???????????,????????(AMD) ????AMD?????AMD?

?AMD??10????? (VEGF)??????AMD????????????VEGF??b???

?b?????3+Q3M3+PRN?b3+Q1M???????????????????????yb65%

??????????b???20149.18%20.39%201410.82%25.59%

?????????????????????????????̷

????????????????????????????????????????????

????????

(???)
 

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